VASCULAR BIOLOGY Matrix metalloproteinase-2 governs lymphatic vessel formation as an interstitial collagenase
نویسندگان
چکیده
1Laboratory of Tumor and Development Biology, Groupe Interdisciplinaire de Génoprotéomique Appliqué-Recherche (GIGA-Cancer), University of Liège, Liège, Belgium; 2Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, Vlaams Instituut voor Biotechnologie–KULeuven, Leuven, Belgium; 3Unit of Molecular Biology and Genetic Engineering, GIGA-Cancer, University of Liège, Liège, Belgium; 4Department of Ophthalmology, Centre Hospitalier Universitaire (CHU) Liège, Liège, Belgium; 5GIGA-Imaging and Flow Cytometry Platform, and 6Laboratory of Cell and Tissue Biology, GIGA-Neurosciences, University of Liège, Liège, Belgium; 7Laboratory of Neural Circuit Development and Regeneration, Biology Department, KULeuven, Leuven, Belgium; and 8Department of Obstetrics and Gynecology, CHU Liège, Liège, Belgium
منابع مشابه
Matrix metalloproteinase-2 governs lymphatic vessel formation as an interstitial collagenase.
Lymphatic dysfunctions are associated with several human diseases, including lymphedema and metastatic spread of cancer. Although it is well recognized that lymphatic capillaries attach directly to interstitial matrix mainly composed of fibrillar type I collagen, the interactions occurring between lymphatics and their surrounding matrix have been overlooked. In this study, we demonstrate how ma...
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